Focused Review Article
Neurons and objects: the case of auditory cortex
Israel Nelken 1, 2* and Omer Bar-Yosef 3
1 The Silberman Institute of Life Science, Department of Neurobiology, Hebrew University, Israel
2 The Interdisciplinary Center for Neural Computation, Hebrew University, Israel
3 Department of Pediatrics, Safra Children’s Hospital, Sheba Medical Center, Israel
2 The Interdisciplinary Center for Neural Computation, Hebrew University, Israel
3 Department of Pediatrics, Safra Children’s Hospital, Sheba Medical Center, Israel
Sounds are encoded into electrical activity in the inner ear, where they are represented (roughly) as patterns of energy in narrow frequency bands. However, sounds are perceived in terms of their high-order properties. It is generally believed that this transformation is performed along the auditory hierarchy, with low-level physical cues computed at early stages of the auditory system and high-level abstract qualities at high-order cortical areas. The functional position of primary auditory cortex (A1) in this scheme is unclear – is it ‘early’, encoding physical cues, or is it ‘late’, encoding already abstract qualities? Here we argue that neurons in cat A1 already show sensitivity to high-level features of sounds. In particular, these neurons may already show sensitivity to ‘auditory objects’. The evidence for this claim comes from studies in which individual sounds are presented singly and in mixtures. Many neurons in cat A1 respond to mixtures in the same way they respond to one of the individual members in the mixture, and in many cases neurons may respond to a low-level component of the mixture rather than to the acoustically dominant one, even though the same neurons respond to the acoustically-dominant component when presented alone.
Keywords: auditory cortex, complex sounds, cats, electrophysiology, single neurons, auditory objects
Copyright: © 2008 Nelken and Bar-Yosef. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
*Correspondence: Israel Nelken, Dept. of Neurobiology, The Silberman Institute of Life Sciences, Edmund Safra Campus, Givat Ram, Hebrew University, Jerusalem 91904, ISRAEL. e-mail: Israel@cc.huji.ac.il
Citation: Nelken I and Bar-Yosef O (2008) Neurons and objects: the case of auditory cortex. Front. Neurosci. 2,1:107-113. doi:10.3389/neuro.01.009.2008
Received: 02 April 2008; paper pending published: 13 June 2008; accepted: 13 June 2008; published online: 15 July 2008.
Edited by:
Misha Tsodyks, Weizmann Institute of Science, Israel
Reviewed by:
Laurenz Wiskott, Humboldt Universität Berlin, Germany
*Correspondence: Israel Nelken, Dept. of Neurobiology, The Silberman Institute of Life Sciences, Edmund Safra Campus, Givat Ram, Hebrew University, Jerusalem 91904, ISRAEL. e-mail: Israel@cc.huji.ac.il


